How can real-time viscosity monitoring ensure emulsion quality？
của NiuShangshen
The need to characterize emulsion properties are critical in formulation, scale-up, processing and testing of emulsions as well as for the design and development of equipment used in these processes.
Viscosity is key to finding a way to measure emulsion quality so that some degree of consistency from one batch to another can be maintained.
Conventional production methods for emulsions are based on quasi continuous processes.
Continuous mixing process consists of controlled dosing of components, adapting and adjusting to the fluid conditions in real-time which can be affected by multiple parameters.
Increase overall throughput and efficiency of homogenization processes
Ultra-high shear rotor/stator systems speed up cycle time by reducing the number of passes required through a high-pressure homogenizer, an inherently low-throughput, high-energy device. Since homogenizers are also generally maintenance-intensive, an efficient ‘pre-mixer’ generates significant savings in the overall cost of production. In certain applications, ultra-high shear mixers even offer a viable alternative to homogenizers.
The sensitive chemistry of the emulsions means that time and cost savings cannot come at the expense of quality, which needs to remain very high. Monitoring & controlling viscosity to optimise the batch processes ensures consistency, quality and significant material cost savings and accurate end point detection/stability estimation of the mixing process for a particular batch. Process control and traceability of the continuous mixing process can be improved with inline monitoring and control of viscosity, which also ensure high level of product consistency, repeatability in the processes and significantly lower reject rates.
Other uses of viscosity measurements include using the data provided by the equipment in formulations and research and development of formulations to exhibit target properties and for an effective characterization. In addition, for pharmaceuticals and food manufacturing, traceability of the process is important for regulatory bodies and inline measurements achieve complete track and trace of the products across the production cycle.
Viscosity is key to finding a way to measure emulsion quality so that some degree of consistency from one batch to another can be maintained.
Conventional production methods for emulsions are based on quasi continuous processes.
Continuous mixing process consists of controlled dosing of components, adapting and adjusting to the fluid conditions in real-time which can be affected by multiple parameters.
Increase overall throughput and efficiency of homogenization processes
Ultra-high shear rotor/stator systems speed up cycle time by reducing the number of passes required through a high-pressure homogenizer, an inherently low-throughput, high-energy device. Since homogenizers are also generally maintenance-intensive, an efficient ‘pre-mixer’ generates significant savings in the overall cost of production. In certain applications, ultra-high shear mixers even offer a viable alternative to homogenizers.
The sensitive chemistry of the emulsions means that time and cost savings cannot come at the expense of quality, which needs to remain very high. Monitoring & controlling viscosity to optimise the batch processes ensures consistency, quality and significant material cost savings and accurate end point detection/stability estimation of the mixing process for a particular batch. Process control and traceability of the continuous mixing process can be improved with inline monitoring and control of viscosity, which also ensure high level of product consistency, repeatability in the processes and significantly lower reject rates.
Other uses of viscosity measurements include using the data provided by the equipment in formulations and research and development of formulations to exhibit target properties and for an effective characterization. In addition, for pharmaceuticals and food manufacturing, traceability of the process is important for regulatory bodies and inline measurements achieve complete track and trace of the products across the production cycle.